PSB-12379, a nucleotide analogue, is a potentEcto-5'-Nucleotidase(CD73) inhibitor withK_is of 9.03 nM (rat) and 2.21 nM (human)^[1][2].

Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)^[1]

Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction^[1].

529.38

Solid

C₁₉H₂₅N₅O₉P₂

1802226-78-3

Room temperature in continental US; may vary elsewhere.

H₂O : 125 mg/mL(236.13 mM;Need ultrasonic)

DMSO : ≥ 5 mg/mL(9.45 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (188.90 mM); Clear solution; Need ultrasonic