CAS NO: | 2641484-61-7 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | MK-0159 (compound 37) is an orally active, potent and selectiveCD38inhibitor, withIC50values of 22, 3, and 70 nM for human, mouse and ratCD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+(nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1]. | ||||||||||||||||
IC50& Target | IC50: 3 nM (mouse CD38), 22 ± 5 nM (hCD38), 70 nM (rat CD38)[1] | ||||||||||||||||
分子量 | 400.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H24N4O3S | ||||||||||||||||
CAS 号 | 2641484-61-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(249.69 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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