CAS NO: | 222638-67-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | BEC hydrochloride is a slow-binding and competitiveArginaseIIinhibitor withKiof 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively[1]. | ||||||||||||||||
IC50& Target | Ki: 0.31 μM (BEC hydrochloride, at pH 7.5) and 30 nM (BEC hydrochloride, at pH 9.5)[1] | ||||||||||||||||
体外研究 (In Vitro) | The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 A resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction[2]. | ||||||||||||||||
体内研究 (In Vivo) | Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness[3].
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分子量 | 229.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C5H13BClNO4S | ||||||||||||||||
CAS 号 | 222638-67-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 50 mg/mL(217.87 mM;Need ultrasonic) H2O : 5 mg/mL(21.79 mM;Need ultrasonic) 配制储备液
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