Glucocorticoid receptor modulator1 is a highly potent and orally active non-steroidal selectiveglucocorticoid receptormodulator with anIC₅₀value of 9 nM and 130 nM forNF-κBandAP-1, respectively.Glucocorticoid receptor modulator1 can effectively reduce the expression of inflammatory factorsIL-6, IL-1β, TNF-α, also can relieve dermatitis in mice^[1].

IC₅₀: 9 nM (NF-κB), 130 nM (AP-1)^[1]

Glucocorticoid receptor modulator 1 (compound B53) shows inhibitory activities against NF-κB and AP-1 with IC₅₀s of 9 nM and 130 nM, respectively^[1].
Glucocorticoid receptor modulator 1 (10 μM; 24 h) decreases the mRNA expression of the inflammatory factors of IL-6, IL-1β, TSLP, MMP-13, TNF-α, and CCL-2^[1].

Glucocorticoid receptor modulator 1 (5, 10 and 20 mg/kg; p.o.; for 24 days) relieves dermatitis in mice and suppresses the expression of inflammatory factors^[1].

470.97

C₂₄H₂₃ClN₂O₄S

2868357-11-1

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