CAS NO: | 2055990-90-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CCG258208 (GRK2-IN-1) is a potent and selectiveGRK2(G protein-coupled receptor kinase2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM),PKA, andROCK1. CCG258208 can be used in heart failure research[1]. | ||||||||
IC50& Target |
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体外研究 (In Vitro) | CCG258208 (Compound 14as) (0-1 μM; 10 min) shows significant improvement in βAR-stimulated contractility in mouse cardiomyocytes[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | CCG258208 (Compound 14as) (intraperitoneal injection; 10 mg/kg; once) treatment shows superior half-life in vivo[1].
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分子量 | 452.48 | ||||||||
Formula | C24H25FN4O4 | ||||||||
CAS 号 | 2055990-90-2 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |