CAS NO: | 2770300-35-9 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | KR-39038 is an orally active and potentGRK5(G protein-coupled receptor kinase 5) inhibitor, with anIC50of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression ofHDAC5pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research[1]. | ||||||||||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | KR-39038 (0-1.0 μM, 24 h) significantly inhibits angiotensin II-induced cellular hypertrophy and HDAC5 phosphorylation in neonatal cardiomyocytes[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | KR-39038 (0-30 mg/kg, Orally, once daily for 14 days) effectively attenuates both cardiac hypertrophy and dysfunction in experimental heart failure[1].
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