PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83^[1].

Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN^[2].
PEN binds and activates a GPCR in the brain^[2].

2215.46

Solid

C₉₇H₁₅₉N₂₇O₃₂

597578-70-6

AADHDVGSELPPEGVLGALLRV

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)