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SB756050
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB756050图片
CAS NO:447410-57-3
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
SB756050 是选择性的TGR5激动剂。SB756050有潜力用于二型糖尿病的研究。
生物活性

SB756050 is a selectiveTGR5agonist. SB756050 has the potential for type 2 diabetes treatment.

体外研究
(In Vitro)

TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D)[1].

体内研究
(In Vivo)

SB756050 is well‐ olerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different[1].

Clinical Trial
分子量

500.59

性状

Solid

Formula

C21H28N2O8S2

CAS 号

447410-57-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 150 mg/mL(299.65 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.9976 mL9.9882 mL19.9764 mL
5 mM0.3995 mL1.9976 mL3.9953 mL
10 mM0.1998 mL0.9988 mL1.9976 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。