TUG-499 is a selectivefree fatty acid receptor1 (FFAR1 or GPR40)(Free Fatty Acid Receptor) agonist with apEC₅₀of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptorPPARγand other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes^[1].

pEC50: 7.39 (FFAR1)^[1]

TUG-499 (compound 7) demonstrates high chemical stability, no inhibition of selected CYP enzymes or P-glycoprotein, and excellent Caco-2 permeability. TUG-499 has potent activity on recombinant human FFA1 receptors and on the rat insulinoma cell line INS-1E^[1].

320.17

C₁₆H₁₁Cl₂NO₂

1206629-08-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.