您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > WKYMVM-NH2 TFA
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
WKYMVM-NH2 TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WKYMVM-NH2 TFA图片
CAS NO:1435781-74-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
WKYMVM-NH2 TFA 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂,同时可以激活一些白细胞效应功能,如趋化性、激活补体受体-3 及 NADPH 氧化酶。
生物活性

WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of theNADPH oxidase[1][2][3].

体外研究
(In Vitro)

WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation[3].

Cell Proliferation Assay[3]

Cell Line:Caco-2 cells (the intestinal epithelial cells)
Concentration:0 nM, 10 nM, 100 nM, 1000 nM
Incubation Time:24 hours
Result:Induced cell proliferation.
体内研究
(In Vivo)

WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis[3].
WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model[3].

Animal Model:Six-week-old C57BL/6 mice, DSS model[3]
Dosage:8 mg/kg
Administration:Subcutaneously injected, six subcutaneous administrations at 12-h intervals, for 5 days
Result:Attenuated the DSS-induced increase in the bleeding score and the stool score.
分子量

970.13

性状

Solid

Formula

C43H62F3N9O9S2

CAS 号

1435781-74-0

Sequence Shortening

WKYMVM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 12.5 mg/mL(12.88 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.0308 mL5.1539 mL10.3079 mL
5 mM0.2062 mL1.0308 mL2.0616 mL
10 mM0.1031 mL0.5154 mL1.0308 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。