您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Endothelin 1(swine,human)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Endothelin 1(swine,human)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:117399-94-7
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
内皮缩血管肽 1 (猪,人)
产品介绍
Endothelin 1 (swine, human) 是具有人和猪内皮素1序列的合成肽,是有效的内源性血管收缩剂。Endothelin 1 通过两种类型受体ETA和ETB发挥作用。
生物活性

Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptorsETAandETB[1].

IC50& Target

ETA

 

ETB

 

体外研究
(In Vitro)

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].

分子量

2491.90

性状

Solid

Formula

C109H159N25O32S5

CAS 号

117399-94-7

Sequence

Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

Sequence Shortening

CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

中文名称

内皮缩血管肽 1 (猪,人)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-80°C2 years
-20°C1 year
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 1.82 mg/mL(0.73 mM;ultrasonic and adjust pH to 3 with HCl)