SAE-14

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SAE-14

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1241280-25-0

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品名称

GPR183 antagonist-1

产品介绍

SAE-14 (compound SAE-14) 是一种有效、特异的GPR183拮抗剂，IC₅₀值为 28.5 nM，可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导，IC₅₀值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。

生物活性

SAE-14 (compound SAE-14) is a potent, specificGPR183antagonist with anIC₅₀value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization withIC₅₀value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice^[1].

IC₅₀& Target

IC50: 28.5 nM (GPR183)^[1]

体外研究
(In Vitro)

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC₅₀value below 50 nM^[1].

Cell Viability Assay^[1]

Cell Line:	The human leukemia (HL)-60 cells
Concentration:	5×of the antagonist
Incubation Time:	15 min
Result:	Had GPR183-specific (IC₅₀: 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.

体内研究
(In Vivo)

SAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice^[1].

Animal Model:	Male and female ICR mice^[1]
Dosage:	2.9 μM
Administration:	intrathecal (i.th.) injections; 2.9 μM; once
Result:	Reversed CCI-induced mechanical allodynia in a time-dependent manner.

分子量

364.36

性状

Solid

Formula

C₁₉H₁₉F₃N₂O₂

CAS 号

1241280-25-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(274.45 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7445 mL	13.7227 mL	27.4454 mL
5 mM	0.5489 mL	2.7445 mL	5.4891 mL
10 mM	0.2745 mL	1.3723 mL	2.7445 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。