Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist ofCRF receptorwithpEC₅₀s of 11.46, 9.36 and 9.85 for human CRF₁, human CRF₂and rat CRF_2αreceptors in CHO cells, andK_is of 0.4, 1.8, and 5.7 nM for hCRF₁, rCRF_2αand mCRF_2βreceptors, respectively^[1][2].

pEC50: 11.46 (human CRF₁, CHO cells), 9.36 (human CRF₂, CHO cells), 9.85 (rat CRF_2α, CHO cells)^[1]
Ki: 0.4 nM (hCRF₁, cell assay), 1.8 nM (rCRF_2α, cell assay), and 5.7 nM (mCRF_2β, cell assay)^[2]

Urotensin I is 2-3 times more potent than CRF or sauvagine in stimulating ACTH release from a superfused goldfish anterior pituitary cell column^[3].
Rat tail artery strips were incubated in the presence of 4 x 10(-3) M theophylline and Urotensin I (UI). At the concentrations of 1.50, 7.50 mU/ml but not of 0.75 mU/ml Urotensin I, the content of cAMP increased significantly^[4].

Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion was suppressed with betamethasone^[3].

4869.46

C₂₁₀H₃₄₀N₆₂O₆₇S₂

83930-33-0

Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2

NDDPPISIDLTFHLLRNMIEMARIENEREQAGLNRKYLDEV-NH2

硬骨鱼紧张肽I

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.