包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | CRF, bovine (TFA) is a potent agonist ofCRF receptor, and displaces [125I-Tyr]ovine CRF with aKiof 3.52 nM[1]. | ||||||||||||||||||||
IC50& Target | Ki: 3.52 nM (CRF receptor)[1]. | ||||||||||||||||||||
体外研究 (In Vitro) | CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Kiof 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8.70 for human CRF1, human CRF2and rat CRF2α[2]. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC[3]. | ||||||||||||||||||||
分子量 | 4811.36 | ||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||
Formula | C208H341F3N60O65S | ||||||||||||||||||||
Sequence | Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Asn-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2 | ||||||||||||||||||||
Sequence Shortening | SQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIA-NH2 | ||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||||||
Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table:
3. Recommended solution:
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