Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitiveCRF₂receptorpeptidic antagonist. Antisauvagine-30 TFA exhibits aK_dof 1.4 nM and 150 nM for mCRFR2β andCRFR1, respectively^[1][2][3][4].

Kd: 1.4 nM (mCRFR2β), 150 nM (CRFR1).

Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice^[1][2].

Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice^[2].
Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect^[3].

3764.28

Solid

C₁₆₃H₂₇₅N₄₈F₃O₄₉S

{D-Phe}-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 25 mg/mL(6.64 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。