Urocortin II,mouse

立即咨询

Urocortin II,mouse

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

330648-32-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Urocortin II, mouse 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，对 CRFR2 和 CRFR1 的K_i值分别为 0.66 nM 和 ﹥100 nM。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca²⁺/CaMKII 依赖性方式激活 CRF2 受体。Urocortin II, mouse 在中枢神经系统的离散区域表达，并激活参与内脏感觉信息处理和调节自主神经外流的中枢神经元。

生物活性

Urocortin II, mouse is a potent and selective endogenous peptide agonist oftype-2 corticotropin-releasing factor (CRF2) receptorwithK_ivalues of 0.66 nM and ﹥100 nM forCRFR2andCRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow^[1]^[2]^[3].

IC₅₀& Target^[2]

CRFR2

0.66 nM (Ki)

CRFR1

﹥100 nM (Ki)

体外研究
(In Vitro)

Urocortin II, mouse 通过激活 CRF2 受体在小鼠心室肌细胞中引起正性肌力和正性变性作用^[1]。
Urocortin II, mouse 通过以 cAMP/PKA 和 Ca²⁺/CaMKII 依赖性方式激活 CRF2 受体^[1]。

体内研究
(In Vivo)

Urocortin II, mouse (1-10 μg; icv and i.v.; 成年雄性 SD 大鼠) 诱导 Fos 的表达^[2]。
Urocortin II, mouse (1 μg; icv; 成年雄性 SD 大鼠) 参与中枢自主神经系统和食欲控制^[2]。

Animal Model:	Adult male Sprague-Dawley rats (250-300 g)^[2]
Dosage:	1, 5, and 10 μg
Administration:	Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration
Result:	Induced Fos expression in a dose-dependent manner.

Animal Model:	Adult male Sprague-Dawley rats (250-300 g)^[2]
Dosage:	1 μg
Administration:	Intracerebroventrical injection
Result:	Reduced food intake over the 12-h interval.

分子量

4152.96

Formula

C₁₈₇H₃₂₀N₅₆O₅₀

CAS 号

330648-32-3

Sequence Shortening

VILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHV-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.