Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenousCRF₂receptor, withK_is of 0.4, 0.3, and 0.5 nM for hCRF₁, rCRF_2αand mCRF_2β, respectively.

Ki: 0.4 nM (hCRF₁, cell assay), 0.3 nM (rCRF_2α, cell assay), and 0.5 nM (mCRF_2β, cell assay)^[1]

Urocortin, human is a selective agonist of CRF₂receptor, with K_is of 0.4, 0.3, and 0.5 nM for human CRF₁, rat CRF_2αand mouse CRF_2βreceptors in cell assay, respectively^[1].

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior^[2].

4696.24

Solid

C₂₀₄H_337N63O64

176591-49-4

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)