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Verucerfont
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Verucerfont图片
CAS NO:885220-61-1
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
GSK561679
产品介绍
Verucerfont 是促肾上腺皮质激素释放因子受体 1 (CRF1) 的拮抗剂,对于 CRF1,CRF2 和 CRF-BP 的IC50值分别为 6.1,>1000 和 >1000 nM。
生物活性

Verucerfont is acorticotropin-releasing factor receptor 1(CRF1) antagonist withIC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.

IC50& Target

IC50: 6.1 nM (CRF1), >1000 nM (CRF2), >1000 nM (CRF-BP)[1]

体内研究
(In Vivo)

Post hocanalysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316 311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20,140]=6.4, P<0.001). Accordingly, detailedPost hocanalysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6 h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline)[1].

Clinical Trial
分子量

406.48

性状

Solid

Formula

C22H26N6O2

CAS 号

885220-61-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL(205.00 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4601 mL12.3007 mL24.6015 mL
5 mM0.4920 mL2.4601 mL4.9203 mL
10 mM0.2460 mL1.2301 mL2.4601 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。