A71623

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A71623

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

130408-77-4

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

A71623 是一种有效且高度选择性的CCK-A激动剂。A-71623 对 CCK-A 和 CCK-B 的IC₅₀分别为 3.7 nM 和 4500 nM。

生物活性

A71623, a CCK-4-based peptide, is a potent and highly selectiveCCK-Afull agonist. TheIC₅₀s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively^[1].

IC₅₀& Target

IC50: 3.7 nM (CCKA receptor in radioligand binding assays)^[1]

体外研究
(In Vitro)

In guinea pig gastric glands, the affinities of A-71623 for the cholecystokinin (CCK)-B/gastrin receptor were 11 μM^[1].

体内研究
(In Vivo)

A71623 (A-63387; i.c.v., but not i.p., injections) reduces food intakes and suppresses intakes of a liquid diet in both deprived and sated rats^[2].
A71623 dampens Purkinje neuron pathology and associates deficits in motor performance inPcp2-ATXN1[30Q]D776;Cck^-/-andPcp2-AXTN1[82Q]mice^[3].
A71623 improves motor performance ofPcp2-ATXN2[127Q]SCA2 mice^[3].

Animal Model:	Adult male, Sprague-Dawley rats^[2]
Dosage:	5 μL
Administration:	Intracerebroventricular (i.c.v) administration, A-71623 was infused using a 28 gauge injection cannula in a volume of 5uL over 60 s
Result:	Reduced food intakes and suppressed intakes of a liquid diet.

Animal Model:	ATXN1[30Q]-D776, ATXN1[82Q]-D776, ATXN2[127Q], and WT/FVB/NJ mice^[3]
Dosage:	0.02 mg/kg/day
Administration:	Osmotic minipumps containing either A71623 (0.02mg/kg/day) were implanted intraperitoneally (i.p.)
Result:	Treatment dampened Purkinje neuron pathology inATXN1[30Q]D776;Cck^-/-mice andATXN1[82Q]mice. Improved motor performance inATXN2[127Q]mice.

分子量

840.96

性状

Solid

Formula

C₄₄H₅₆N₈O₉

CAS 号

130408-77-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(59.46 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.1891 mL	5.9456 mL	11.8912 mL
5 mM	0.2378 mL	1.1891 mL	2.3782 mL
10 mM	0.1189 mL	0.5946 mL	1.1891 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。