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Adrenomedullin(AM)(22-52),human
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:159899-65-7
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
22-52-Adrenomedullin (human)
产品介绍
Adrenomedullin (AM) (22-52), human,NH2末端截短的 adrenomedullin 类似物, 为肾上腺髓质素 (adrenomedullin receptor) 受体拮抗剂,同时在猫后肢血管床中,对降钙素基因相关肽 (CGRP) 受体也具有拮抗作用。
生物活性

Adrenomedullin(AM) (22-52), human, an NH2 terminal truncatedadrenomedullinanalogue, is anadrenomedullinreceptorantagonist, and also antagonizes thecalcitoningenerelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1][2].

IC50& Target

Adrenomedullin receptor, CGRP receptor[1]

体外研究
(In Vitro)

Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells[1].

分子量

3576.04

性状

Solid

Formula

C159H252N46O48

CAS 号

159899-65-7

Sequence

Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

Sequence Shortening

TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 50 mg/mL(13.98 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.2796 mL1.3982 mL2.7964 mL
5 mM0.0559 mL0.2796 mL0.5593 mL
10 mM0.0280 mL0.1398 mL0.2796 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。