您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > CCR6 antagonist 1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CCR6 antagonist 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCR6 antagonist 1图片
CAS NO:588674-64-0
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
CCR6 antagonist 1 是一种CCR6拮抗剂,可抑制CCL20/CCR6信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究,如炎症性肠病 (IBDs)。
生物活性

CCR6 antagonist1 is aCCR6antagonist that inhibits theCCL20/CCR6axis.CCR6 antagonist1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1].

IC50& Target[1]

CCR6

 

体外研究
(In Vitro)

CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4+T cell migration[1].
CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively[1].

Cell Migration Assay[1]

Cell Line:CCL20 (500 ng/mL)-induced CCR6+CD4+T cell
Concentration:0.5, 5, 50 μM
Incubation Time:3 h
Result:Inhibited CCL20-induced cell migration at 50 μM.
体内研究
(In Vivo)

CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice[1].

Animal Model:Murine model of colitis (5 mg/mouse TNBS-induced)[1]
Dosage:1 mg/kg
Administration:Subcutaneous injection (s.c.), twice daily for 3 days.
Result:Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.
Animal Model:Zymosan-induced peritonitis mice[1]
Dosage:1 mg/kg
Administration:Subcutaneous injection (s.c.), twice, before and after zymosan treatment
Result:Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.
分子量

319.28

性状

Solid

Formula

C17H12F3NO2

CAS 号

588674-64-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL(313.20 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.1320 mL15.6602 mL31.3205 mL
5 mM0.6264 mL3.1320 mL6.2641 mL
10 mM0.3132 mL1.5660 mL3.1320 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。