CAS NO: | 284035-33-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potentcalcium ion-sensing receptor (CaSR)antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+concentrations (IC50=43 nM) elicited by activating the Ca2+receptor in HEK 293 cells expressing the human Ca2+receptor[1][2]. | ||||||||||||||||
IC50& Target | IC50: 43 nM (Ca2+receptor) | ||||||||||||||||
体外研究 (In Vitro) | NPS-2143 (SB-262470A) stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+on isoproterenol-stimulated increases in cyclic AMP formation[1]. | ||||||||||||||||
体内研究 (In Vivo) | NPS-2143 (SB-262470A) results in a rapid 4- to 5-fold increase in plasma PTH levels in rats[1]. | ||||||||||||||||
分子量 | 408.92 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H25ClN2O2 | ||||||||||||||||
CAS 号 | 284035-33-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 17.86 mg/mL(43.68 mM;ultrasonic and adjust pH to 2 with H2O) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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