CAS NO: | 1157852-02-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Fasitibant chloride (MEN16132 free base) is a potent and selective nonpeptidebradykinin B2 receptor (B2R)antagonist. Fasitibant chloride reduces joint pain and diminishes joint oedema in Carrageenan-induced arthritis rat model[1][2][3]. | ||||||||
IC50& Target | B2R[1][2] | ||||||||
体外研究 (In Vitro) | Fasitibant chloride (MEN16132 free base; 1 μM; pre-treatment 30 min before BK) produces a consistent reduction of the FGF-2 expression (BK induced) and decrement of BK induced-FGFR-1 phosphorylation[2]. Cell Viability Assay[2]
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体内研究 (In Vivo) | Fasitibant chloride (MEN16132 free base; 100 μg per knee; injection into the knee; 30 min before λ-carrageenan) inhibits about 40-45% on the carrageenan-induced joint pain and knee joint oedema[1].
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Clinical Trial | |||||||||
分子量 | 800.23 | ||||||||
Formula | C36H49Cl3N6O6S | ||||||||
CAS 号 | 1157852-02-2 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |