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Icatibant Acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Icatibant Acetate图片
CAS NO:138614-30-9
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
HOE 140 acetate
产品介绍
Icatibant acetate (HOE-140 acetate) 是有效的,特异的缓激肽 B2 受体拮抗剂,IC50Ki值分别为 1.07 nM和 0.798 nM。
生物活性

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist ofbradykinin B2 receptorwith anIC50andKiof 1.07 nM and 0.798 nM respectively[1][2][3].

体外研究
(In Vitro)

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

体内研究
(In Vivo)

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

Animal Model:Female mice of the CBA/J (H-2k) strain[2].
Dosage:0.06, 0.3, or 1.5 mg/kg.
Administration:Subcutaneous administration twice daily.
Result:The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Clinical Trial
分子量

1364.57

性状

Solid

Formula

C61H93N19O15S

CAS 号

138614-30-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL(73.28 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.7328 mL3.6642 mL7.3283 mL
5 mM0.1466 mL0.7328 mL1.4657 mL
10 mM0.0733 mL0.3664 mL0.7328 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。