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m-PEG4-Br
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG4-Br图片
CAS NO:110429-45-3
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
m-PEG4-Br 是可降解 (cleavable) 的 ADC linker,用于合成曲妥珠单抗 的抗体偶联药物 (ADC)。m-PEG4-Br 被置于单甲基澳瑞他汀 E (MMAE) 有效载荷的远端,以产生具有改变的亲水性,抗原结合和体外效能的 ADC。Tetraethylene glycol monotosylate 也可用作 PROTAC 的 Linker,可用于 PROTAC 的合成。$
Cas No.110429-45-3
分子式C9H19BrO4
分子量271.15
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG4-Br is a cleavableADC linkerused in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab . m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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