Apelin-13

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Apelin-13

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

217082-58-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Apelin-13 是G 蛋白偶联受体angiotensin II protein J (APJ)的内源性配体，激活G蛋白偶联受体的EC₅₀值为 0.37 nM。Apelin-13 广泛分布于中枢和外周神经系统。Apelin-13 具有扩张血管和降压作用。Apelin-13 也可用于 2 型糖尿病综合征的研究。

生物活性

Apelin-13 is an endogenous ligand for theG-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with anEC₅₀value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome^[1]^[2]^[3].

IC₅₀& Target

IC₅₀: 0.37 nM (APJ)^[1]

体内研究
(In Vivo)

Apelin-13 (200 μg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels^[2].
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons^[4].

Animal Model:	Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)^[2]
Dosage:	200 μg/kg
Administration:	IP, daily for 4 weeks
Result:	Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.

Animal Model:	Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)^[4]
Dosage:	10 and100 μM
Administration:	ICV, single dosage
Result:	Increased the spontaneous discharges in the majority of pallidal neurons.

Clinical Trial

分子量

1550.83

Formula

C₆₉H₁₁₁N₂₃O₁₆S

CAS 号

217082-58-1

Sequence

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe

Sequence Shortening

QRPRLSHKGPMPF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.