MM 54

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MM 54

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1313027-43-8

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

MM 54 (compound 5) 是竞争性的APJ拮抗剂，其IC₅₀值为 93 nM。MM 54作为一种有效的和选择性的 apelin 结合和 APLNR 激活的抑制剂。

生物活性

MM 54 (compound 5) is a competitive antagonist atAPJ, with anIC₅₀of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation^[1]^[2].

体外研究
(In Vitro)

MM 54 inhibits more than 95% of apelin binding to APLNR at the dose of 10 μM^[2].

体内研究
(In Vivo)

MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity^[2].

Animal Model:	Tumour-bearing nude-mice^[2].
Dosage:	2 mg/kg.
Administration:	Intraperitoneal injection, bi-weekly for 4 weeks.
Result:	Reduced tumor progression (glioblastoma).

分子量

1737.17

Formula

C₇₀H₁₂₁N₂₉O₁₅S₄

CAS 号

1313027-43-8

Sequence Shortening

CRPRLCKHCRPRLC (Disulfide bridge:Cys1-Cys6; Cys9-Cys14)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.