PD 123319 (ditrifluoroacetate) is a potent, selectiveAT2 angiotensin II receptorantagonist withIC₅₀of 34 nM.

IC50: 34 nM (AT2 Receptor)^[1]

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. ¹²⁵I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC₅₀of 92.9 nM) for DuP-753. PD-123319 does not have any effect on ¹²⁵I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC₅₀of 6.9 nM, and has a much lower affinity for DuP-753 (IC₅₀around 10 microM)^[2].

736.66

Solid

C₃₅H₃₄F₆N₄O₇

136676-91-0

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : ≥ 36 mg/mL(48.87 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (135.75 mM); Clear solution; Need ultrasonic