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PD 123319 ditrifluoroacetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD 123319 ditrifluoroacetate图片
CAS NO:136676-91-0
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
PD 123319 ditrifluoroacetate 是一种有效的,选择性的AT2 angiotensin II receptor拮抗剂,IC50值为 34 nM。
生物活性

PD 123319 (ditrifluoroacetate) is a potent, selectiveAT2 angiotensin II receptorantagonist withIC50of 34 nM.

IC50& Target

IC50: 34 nM (AT2 Receptor)[1]

体外研究
(In Vitro)

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50of 6.9 nM, and has a much lower affinity for DuP-753 (IC50around 10 microM)[2].

分子量

736.66

性状

Solid

Formula

C35H34F6N4O7

CAS 号

136676-91-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : ≥ 36 mg/mL(48.87 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.3575 mL6.7874 mL13.5748 mL
5 mM0.2715 mL1.3575 mL2.7150 mL
10 mM0.1357 mL0.6787 mL1.3575 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (135.75 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。