Losartan potassium

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Losartan potassium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

124750-99-8

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
500mg	电议
1 g	电议
5 g	电议
10 g	电议
50 g	电议

产品名称

氯沙坦钾
DuP-753 potassium

产品介绍

Losartan potassium (DuP-753 potassium) 是血管紧张素 II 受体 1 型 (AT1)拮抗剂，与血管紧张素 II 与 AT1 的结合竞争，IC₅₀为 20 nM。

生物活性

Losartan potassium (DuP-753 potassium) is anangiotensin II receptor type 1 (AT1)antagonist, competing with the binding of angiotensin II to AT1 with anIC₅₀of 20 nM.

IC₅₀& Target

IC50: 20 nM (angiotensin II)

体外研究
(In Vitro)

Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC₅₀) is 20 nM^[1]. Losartan (40 μM) affectsI_SCbut prevents the effect of ANGII onI_SC^[2]. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone^[3].

体内研究
(In Vivo)

Losartan (0.6 g/L, p.o.) -treatedFbn1^C1039G/+mice show a reduction in distal airspace caliber relative to placebo-treatedFbn1^C1039G/+animals. The doses of losartan and propranolol are titrated to achieve comparable hemodynamic effects. Analysis of pSmad2 nuclear staining reveals that losartan antagonizes TGF-β signaling in the aortic wall ofFbn1^C1039G/+mice. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics^[4]. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged^[5].

Clinical Trial

分子量

461.00

性状

Solid

Formula

C₂₂H₂₂ClKN₆O

CAS 号

124750-99-8

中文名称

氯沙坦钾

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : ≥ 110 mg/mL(238.61 mM)

H₂O : 50 mg/mL(108.46 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1692 mL	10.8460 mL	21.6920 mL
5 mM	0.4338 mL	2.1692 mL	4.3384 mL
10 mM	0.2169 mL	1.0846 mL	2.1692 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (216.92 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。