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Boc-NH-PEG1-CH2CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Boc-NH-PEG1-CH2CH2COOH图片
CAS NO:1260092-44-1
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Boc-NH-PEG1-CH2CH2COOH 是一种可降解 (cleavable) 的含 1 个单元 PEG 的 ADC linker,同时也是 PROTAC linker,属于 PEG 和 Alkyl/ether 类,可用于合成抗体偶联药物 (ADC) 和 PROTAC。
Cas No.1260092-44-1
分子式C10H19NO5
分子量233.26
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also aPEG- andAlkyl/ether-basedPROTAC linkercan be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].