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DBCO-PEG5-NHS ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DBCO-PEG5-NHS ester图片
CAS NO:2144395-59-3
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
DBCO-PEG5-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类,用于合成一系列 PROTAC 分子。DBCO-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
Cas No.2144395-59-3
分子式C36H43N3O11
分子量693.74
溶解度DMSO : ≥ 100 mg/mL (144.15 mM)
储存条件Store at -20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-basedPROTAC linkercan be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1][2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.