您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Boc-C14-COOH
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Boc-C14-COOH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Boc-C14-COOH图片
CAS NO:843666-27-3
包装与价格：
包装价格(元)
500mg电议
1g电议

产品介绍
Boc-C14-COOH 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。Boc-C14-COOH 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
Cas No.843666-27-3
分子式C20H38O4
分子量342.51
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].