您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > AC 187
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
AC 187
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:151804-77-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AC 187 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂,IC50为 0.48 nM,Ki为 0.275 nM。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 具有神经保护作用。
生物活性

AC 187 is a potent and orally activeamylin receptorantagonist with anIC50of 0.48 nM and aKiof 0.275 nM. AC 187 shows more selective foramylin receptorthancalcitoninand CGRP receptors. AC 187 has neuroprotective effects[1][2].

IC50& Target

IC50: 0.48 nM (amylin receptor)

体外研究
(In Vitro)

AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1].
AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death[1].

体内研究
(In Vivo)

AC 187 (30 mg/mL) increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia in hyperinsulinemic clamps in Sprague-Dawley (HSD) rats[2].

分子量

2890.25

Formula

C127H205N37O40

CAS 号

151804-77-2

Sequence

Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2

Sequence Shortening

Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.