CAS NO: | 151804-77-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | AC 187 is a potent and orally activeamylin receptorantagonist with anIC50of 0.48 nM and aKiof 0.275 nM. AC 187 shows more selective foramylin receptorthancalcitoninand CGRP receptors. AC 187 has neuroprotective effects[1][2]. |
IC50& Target | IC50: 0.48 nM (amylin receptor) |
体外研究 (In Vitro) | AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1]. |
体内研究 (In Vivo) | AC 187 (30 mg/mL) increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia in hyperinsulinemic clamps in Sprague-Dawley (HSD) rats[2]. |
分子量 | 2890.25 |
Formula | C127H205N37O40 |
CAS 号 | 151804-77-2 |
Sequence | Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 |
Sequence Shortening | Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |