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m-PEG12-OH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG12-OH图片
CAS NO:2050595-03-2
包装与价格:
包装价格(元)
500mg电议
1g电议

产品介绍
m-PEG12-OH 是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。m-PEG12-OH 也是一种不可降解 (non-cleavable) 的含 12 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
Cas No.2050595-03-2
分子式C25H52O13
分子量560.67
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG12-OH is a PEG-basedPROTAC linkerthat can be used in the synthesis of PROTACs[1]. m-PEG12-OH is also a non-cleavable 12 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].