CAS NO: | 61-76-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
生物活性 | (R)-(-)-Phenylephrine hydrochloride is a selectiveα1-adrenoceptoragonist withpKisof 5.86, 4.87 and 4.70 for α1D, α1Band α1Areceptors respectively. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | (R)-(-)-Phenylephrine is a selectiveα1-adrenoceptoragonist with pKivalues of 5.86, 4.87 and 4.70 for α1D, α1Band α1Areceptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3]. | ||||||||||||||||
体内研究 (In Vivo) | Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema[5]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 203.67 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C9H14ClNO2 | ||||||||||||||||
CAS 号 | 61-76-7 | ||||||||||||||||
中文名称 | 盐酸去氧肾上腺素 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 125 mg/mL(613.74 mM;Need ultrasonic) H2O : 100 mg/mL(490.99 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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