PNU-282987 is a potentα7 nicotinic acetylcholine receptor (nAChR)agonist with anEC₅₀of 154 nM. PNU-282987 is also a functional antagonist of the5-HT₃receptorwith anIC₅₀of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems^[1].

IC50: 4541nM (5-HT₃); EC50: 154 nM (α7 nAChR); Ki: 27 nM (R7 MLA)^[1]

PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a K_iof 27 nM^[1].
PNU-282987 has α7 nAChR agonist activity with an EC₅₀of 154 nM^[1].
PNU-282987 also has inhibition for the 5-HT₃receptor with an IC₅₀value of 4541nM^[1].

PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit^[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner^[1].

301.21

Solid

C₁₄H₁₈Cl₂N₂O

123464-89-1

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : ≥ 61 mg/mL(202.52 mM)

H₂O : 50 mg/mL(166.00 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 50 mg/mL (166.00 mM); Clear solution; Need ultrasonic