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SCH-23390 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SCH-23390 hydrochloride图片
CAS NO:125941-87-9
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
R-(+)-SCH-23390 hydrochloride
产品介绍
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) 是一种有效的选择性的多巴胺D1样受体拮抗剂,其对D1D5受体的Ki分别为 0.2 nM 和 0.3 nM。SCH-23390 hydrochloride 也是一种有效的人5-HT2C受体激动剂,Ki为 9.3 nM。SCH-23390 hydrochloride 与5-HT25-HT1C受体具有高亲和力。SCH-23390 hydrochloride 还抑制 G 蛋白偶联的内向整流钾 (GIRK) 通道,IC50为 268 nM。
生物活性

SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selectivedopamine D1-like receptorantagonist withKis of 0.2 nM and 0.3 nM for theD1andD5receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacyhuman 5-HT2Creceptoragonist with aKiof 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the5-HT2and5-HT1Creceptors. SCH-23390 hydrochloride inhibitsG protein-coupled inwardly rectifying potassium (GIRK) channelswith anIC50of 268 nM[1][2][3].

IC50& Target[1][2][3]

D1Receptor

0.2 nM (Ki)

D5Receptor

0.3 nM (Ki)

5-HT2CReceptor

9.3 nM (Ki)

GIRK

268 nM (IC50)

体外研究
(In Vitro)

SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].

体内研究
(In Vivo)

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1receptors in rodents, nonhuman primates, and humans[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2conditions[5].

分子量

324.24

性状

Solid

Formula

C17H19Cl2NO

CAS 号

125941-87-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : ≥ 32 mg/mL(98.69 mM)

H2O : 28.57 mg/mL(88.11 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.0841 mL15.4207 mL30.8414 mL
5 mM0.6168 mL3.0841 mL6.1683 mL
10 mM0.3084 mL1.5421 mL3.0841 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40%PEG300   5%Tween-80   45% saline

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.42 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH2O 中,得到澄清透明的生理盐水溶液
*以上所有助溶剂都可在本网站选购。