CAS NO: | 125941-87-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selectivedopamine D1-like receptorantagonist withKis of 0.2 nM and 0.3 nM for theD1andD5receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacyhuman 5-HT2Creceptoragonist with aKiof 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the5-HT2and5-HT1Creceptors. SCH-23390 hydrochloride inhibitsG protein-coupled inwardly rectifying potassium (GIRK) channelswith anIC50of 268 nM[1][2][3]. | ||||||||||||||||
IC50& Target[1][2][3] |
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体外研究 (In Vitro) | SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4]. | ||||||||||||||||
体内研究 (In Vivo) | SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1receptors in rodents, nonhuman primates, and humans[1]. | ||||||||||||||||
分子量 | 324.24 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H19Cl2NO | ||||||||||||||||
CAS 号 | 125941-87-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 32 mg/mL(98.69 mM) H2O : 28.57 mg/mL(88.11 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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