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Nicotinamide riboside chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nicotinamide riboside chloride图片
CAS NO:23111-00-4
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
100mg电议
200mg电议
500mg电议

产品名称
烟酰胺核糖氯酸盐
产品介绍
Nicotinamide riboside Chloride 是具有口服活性的 NAD+的前体,增加 NAD+水平并激活SIRT1SIRT3。Nicotinamide riboside Chloride 是维生素 B3 (烟酸) 的来源,可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。Nicotinamide riboside Chloride 可以减少阿尔茨海默氏病转基因小鼠模型中的认知退化。
生物活性

Nicotinamide riboside Chloride, an orally active NAD+precursor, increases NAD+levels and activatesSIRT1andSIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50& Target[1]

SIRT1

 

SIRT3

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD+content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

Western Blot Analysis[1]

Cell Line:HEK293T cells
Concentration:0.5 nM
Incubation Time:24 hours
Result:Reduced the acetylation status of Ndufa9 and SOD2.
体内研究
(In Vivo)

Chronic Nicotinamide riboside Chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+content in a tissue-specific manner[1].

Animal Model:10-week-old C57Bl/6J mice[1]
Dosage:400 mg/kg
Administration:PO; daily; for 16 weeks
Result:Increased plasma and intracellular NAD+content in a tissue-specific manner.
Clinical Trial
分子量

290.70

性状

Solid

Formula

C11H15ClN2O5

CAS 号

23111-00-4

中文名称

烟酰胺核糖氯酸盐

结构分类
  • Alkaloids
  • Pyridine Alkaloids
来源

milk and beer

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 125 mg/mL(430.00 mM;Need ultrasonic)

DMSO : 50 mg/mL(172.00 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.4400 mL17.1999 mL34.3997 mL
5 mM0.6880 mL3.4400 mL6.8799 mL
10 mM0.3440 mL1.7200 mL3.4400 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 25 mg/mL (86.00 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。