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PAD2-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PAD2-IN-1图片
CAS NO:2095109-82-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PAD2-IN-1,一种基于苯并咪唑的衍生物,是一种有效的选择性蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂。PAD2-IN-1 对PAD2的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)。
生物活性

PAD2-IN-1, a benzimidazole-based derivative, is a potent and selectiveprotein arginine deiminase2 (PAD2)inhibitor. PAD2-IN-1 shows superior selectivity forPAD2over PAD4 (95-fold) and PAD3 (79-fold)[1].

IC50& Target

Protein Arginine Deiminase 2 (PAD2)[1]

体外研究
(In Vitro)

In the target engagement assay, the EC50of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1].
PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC50of 2.7 μM in HEK293T/PAD2 cells[1].

分子量

480.53

Formula

C25H29FN6O3

CAS 号

2095109-82-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.