CAS NO: | 82-08-6 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Rottlerin, a natural product purified fromMallotus Philippinensis, is a specificPKCinhibitor, withIC50values forPKCδof 3-6 μM,PKCα,β,γ of 30-42 μM,PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulatesautophagyby targeting a signaling cascade upstream ofmTORC1. Rottlerin inducesapoptosisviacaspase 3activation[1][2][3]. Rottlerin inhibitsHIV-1integration andRabies virus (RABV)infection[4][5]. | ||||||||||||||||
IC50& Target[1][4] |
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体外研究 (In Vitro) | Rottlerin (20 μM, 2/6/24 hours) dramatically decreases the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC[2]. Western Blot Analysis[2]
Cell Proliferation Assay[2]
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体内研究 (In Vivo) | Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity[3].
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分子量 | 516.54 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C30H28O8 | ||||||||||||||||
CAS 号 | 82-08-6 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(24.20 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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