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Gypenoside LI
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gypenoside LI图片
CAS NO:94987-10-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Gypenoside LI 是一种绞股蓝赶单体,具有抗肿瘤活性。Gypenoside LI 诱导癌细胞凋亡、细胞周期阻滞和迁移。
生物活性

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cellapoptosis, cell cycle and migration[1][2].

体外研究
(In Vitro)

Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells[1].
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells[1].
Gypenoside LI could obviously suppress the expression of CDK1 protein rather than CDK2 and CDK4 proteins[1].
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells[2].
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway[2].
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells[2].

Cell Viability Assay[1]

Cell Line:A549 cells.
Concentration:0-80 μM.
Incubation Time:24 h.
Result:Displayed the strongest activity with the IC50values of 21.36 ± 0.78 μM.
分子量

801.01

性状

Solid

Formula

C42H72O14

CAS 号

94987-10-7

结构分类
  • Terpenoids
  • Triterpenes
来源
  • Plants
  • Cucurbitaceae
  • Gynostemma pentaphyllum(Thunb.) Makino
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL(124.84 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.2484 mL6.2421 mL12.4842 mL
5 mM0.2497 mL1.2484 mL2.4968 mL
10 mM0.1248 mL0.6242 mL1.2484 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。