CAS NO: | 72882-78-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | PF-9366 is a humanmethionine adenosyltransferase2A (Mat2A) inhibitor, with anIC50of 420 nM and aKdof 170 nM. | ||||||||||||||||
IC50& Target | IC50: 420 nM (Mat2A)[1] | ||||||||||||||||
体外研究 (In Vitro) | PF-9366 is a Mat2A inhibitor, with an IC50of 420 nM and a Kdof 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50of 255 nM, and also suppresses the proliferation of cells with an IC50of 10 μM. | ||||||||||||||||
分子量 | 350.84 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H19ClN4 | ||||||||||||||||
CAS 号 | 72882-78-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 10 mg/mL(28.50 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|