CAS NO: | 1334298-90-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Itacitinib (INCB039110) is an orally active and selective inhibitor ofJAK1with anIC50of 2 nM forhumanJAK1. Itacitinib shows >20-fold selectivity forJAK1overJAK2and >100-fold overJAK3andTYK2; Itacitinib is used in the research of myelofibrosis[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 553.51 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C26H23F4N9O | ||||||||||||||||
CAS 号 | 1334298-90-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 30 mg/mL(54.20 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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