CAS NO: | 857064-38-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | WP1066 is an inhibitor ofJAK2andSTAT3, and also shows effect onSTAT5and ERK1/2, without affectingJAK1andJAK3. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | WP1066 markedly inhibits the growth of HEL cells in a dose-dependent manner. The IC50value for inhibition of the proliferation of HEL cells is 2.3 μM. WP1066 inhibits the growth of human HEL cells carrying the JAK2 V617F mutant isoform[1]. Blockade of p-STAT3 with WP1066 enhances the cytotoxic effects of CTX on the tumor. The IC50doses of WP1066 for B16 cells is 2.43 μM (0.865 μg/mL)[2]. WP1066 inhibits AML blast colony-forming cell proliferation, suppresses normal BM progenitor proliferation at increased concentrations, and inhibits AML colony-forming cell proliferation[3]. | ||||||||||||||||
体内研究 (In Vivo) | WP1066 (30 mg/kg, o.g.) exerts an additive effect to CTX inhibition of the p-STAT3 pathway within the tumor microenvironment[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 356.22 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H14BrN3O | ||||||||||||||||
CAS 号 | 857064-38-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 44 mg/mL(123.52 mM) Ethanol : 16.67 mg/mL(46.80 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |