您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > WP1066
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
WP1066
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WP1066图片
CAS NO:857064-38-1
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
WP1066 是一种新颖的JAK2STAT3抑制剂,对 STAT5 和 ERK1/2 也起作用,但对 JAK1 和 JAK3 没有影响。
生物活性

WP1066 is an inhibitor ofJAK2andSTAT3, and also shows effect onSTAT5and ERK1/2, without affectingJAK1andJAK3.

IC50& Target[1][2]

JAK2

 

STAT3

 

体外研究
(In Vitro)

WP1066 markedly inhibits the growth of HEL cells in a dose-dependent manner. The IC50value for inhibition of the proliferation of HEL cells is 2.3 μM. WP1066 inhibits the growth of human HEL cells carrying the JAK2 V617F mutant isoform[1]. Blockade of p-STAT3 with WP1066 enhances the cytotoxic effects of CTX on the tumor. The IC50doses of WP1066 for B16 cells is 2.43 μM (0.865 μg/mL)[2]. WP1066 inhibits AML blast colony-forming cell proliferation, suppresses normal BM progenitor proliferation at increased concentrations, and inhibits AML colony-forming cell proliferation[3].

体内研究
(In Vivo)

WP1066 (30 mg/kg, o.g.) exerts an additive effect to CTX inhibition of the p-STAT3 pathway within the tumor microenvironment[2].

Clinical Trial
分子量

356.22

性状

Solid

Formula

C17H14BrN3O

CAS 号

857064-38-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 44 mg/mL(123.52 mM)

Ethanol : 16.67 mg/mL(46.80 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.8073 mL14.0363 mL28.0725 mL
5 mM0.5615 mL2.8073 mL5.6145 mL
10 mM0.2807 mL1.4036 mL2.8073 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。