CAS NO: | 1092939-17-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Ruxolitinib phosphate (INCB018424 phosphate) is a potentJAK1/2inhibitor withIC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity overJAK3. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC50of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system, and inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples[1]. | ||||||||||||||||
体内研究 (In Vivo) | Ruxolitinib (180 mg/kg, p.o.) reduces the tumor burden of mice inoculated with JAK2V617F-expressing cells without causing anemia or lymphopenia[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 404.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H21N6O4P | ||||||||||||||||
CAS 号 | 1092939-17-7 | ||||||||||||||||
中文名称 | 鲁索利替尼磷酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 31 mg/mL(76.66 mM) H2O : 10 mg/mL(24.73 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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