CAS NO: | 1831110-54-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | MS023 is a potent, selective, and cell-active inhibitor of humantype I protein arginine methyltransferases (PRMTs)inhibitor, withIC50s of 30, 119, 83, 4 and 5 nM forPRMT1,PRMT3,PRMT4,PRMT6, andPRMT8, respectively[1]. | ||||||||||||||||
IC50& Target | IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1] | ||||||||||||||||
体外研究 (In Vitro) | MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells[2].
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分子量 | 287.40 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H25N3O | ||||||||||||||||
CAS 号 | 1831110-54-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 66.67 mg/mL(231.98 mM;Need ultrasonic) DMSO : ≥ 30 mg/mL(104.38 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |