您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > AICAR phosphate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
AICAR phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AICAR phosphate图片
CAS NO:681006-28-0
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
50mg电议
100mg电议
200mg电议
500mg电议
1 g电议
5 g电议

产品名称
Acadesine phosphate
AICA Riboside phosphate
产品介绍
AICAR phosphate (Acadesine phosphate) 是一种腺苷类似物,也是一种AMPK激活剂。AICAR phosphate 调节葡萄糖和脂质的代谢,并抑制促炎细胞因子和 iNOS 的产生。AICAR phosphate 也是一种自噬 (autophagy),YAPmitophagy抑制剂。
生物活性

AICAR phosphate (Acadesine phosphate) is an adenosine analog and aAMPKactivator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines andiNOSproduction. AICAR phosphate is also anautophagy,YAPandmitophagyinhibitor[1][2].

IC50& Target[1]

AMPK

 

Autophagy

 

Mitophagy

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively[1].

体内研究
(In Vivo)

Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt-1*day-1or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change[3]. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups[4].

Clinical Trial
分子量

356.23

性状

Solid

Formula

C9H17N4O9P

CAS 号

681006-28-0

中文名称

阿卡地新磷酸盐

结构分类
  • Alkaloids
  • Other Alkaloids
来源

Body

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(280.72 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.8072 mL14.0359 mL28.0718 mL
5 mM0.5614 mL2.8072 mL5.6143 mL
10 mM0.2807 mL1.4036 mL2.8072 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 33.33 mg/mL (93.56 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。