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PAK1-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PAK1-IN-1图片
CAS NO:2485732-30-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PAK1-IN-1 是一种有效的选择性PAK1抑制剂,IC50为 9.8 nM。PAK1-IN-1以剂量依赖性方式抑制 PAK1 相关肿瘤细胞的迁移和侵袭。
生物活性

PAK1-IN-1 is a potent and selectivePAK1inhibitor with anIC50of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

IC50& Target[1]

PAK1

9.8 nM (IC50)

PAK4

>10 μM (IC50)

体外研究
(In Vitro)

PAK1-IN-1 (compound 30l) (0-10 μM) shows selectivity with IC50s of 0.01, >10 μM for PAK1 and PAK4, respectively[1].

Cell Proliferation Assay[1]

Cell Line:MDA-MB-231, HCT-116 cells
Concentration:1 μM
Incubation Time:72 h
Result:Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.

Western Blot Analysis[1]

Cell Line:MDA-MB-231 cells
Concentration:2.5, 5, 10, 20 μM
Incubation Time:1, 24 h
Result:Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.
分子量

469.92

Formula

C26H20ClN5O2

CAS 号

2485732-30-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.