CAS NO: | 110448-33-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibitsMLCK(IC50=300 nM). ML-7 hydrochloride also inhibitsYAP/TAZ. | ||||||||||||||||
IC50& Target | IC50: 300 nM (MLCK)[1] | ||||||||||||||||
体外研究 (In Vitro) | ML-7 hydrochloride inhibits rabbit portal vein α1-adrenoceptor NSCC with IC50of 0.8 μM[1]. The myosin light chain kinase (MLCK) inhibitor ML-7 hydrochloride (3 μ M and 10 μM) also attenuates the Dexmedetomidine (DMT)-induced contraction (p<0.05 versus control)[2]. | ||||||||||||||||
体内研究 (In Vivo) | In sham operated animals Evans Blue extravasation is not different between ML-7 hydrochloride and vehicle group (sham+vehicle: 0.26±0.02 OD/g; sham+ML-7: 0.26±0.02 OD/g). After CCI inhibition of MLCK with ML-7 results in a significant lower amount of intracerebral Evans Blue compared to vehicle treated animals (CCI+vehicle: 0.42±0.04 OD/g; CCI+ML-7: 0.35±0.05 OD/g, p=0.048)[3]. | ||||||||||||||||
分子量 | 452.74 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H18ClIN2O2S | ||||||||||||||||
CAS 号 | 110448-33-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 43 mg/mL(94.98 mM) H2O : 1.43 mg/mL(3.16 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
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