Cytochalasin D (Zygosporin A) is a potentactin polymerizationinhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount ofsurvivinpresent in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention ofYap^[1][2][3][4].

Cytochalasin D (3 and 10 μM; 30 min) causes retraction and arborization of COS-7 cells and conversion of F-actin from long fibers to punctate structures^[1].
Cytochalasin D (0.3, 1, 3 and 10 μM; 30 min) concentration-dependently decreases the rate of actin depolymerization in COS-7 cells^[1].
Cytochalasin D (1 μM; NIH3T3 cells) disrupts stress fibers, induces phosphorylation of Yap, while cells maintains original area and lost nuclear Yap localization^[4].

507.62

Solid

C₃₀H₃₇NO₆

22144-77-0

细胞松弛素D

• Others

molds

Room temperature in continental US; may vary elsewhere.

DMSO : 25 mg/mL(49.25 mM;ultrasonic and warming and heat to 60℃)

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